ABSTRACT
A cross sectional study on the relation of vaginal fluid secretion syndrome with some risk factors in 340 married women with ages of 15 and older has shown that the rate of vaginal fluid secretion syndrome (VFSS) was 50.6%. There was a relation of VFSS and age when getting married, rounds of pregnancy (3 and above), abortion history, use of unhygienic water and knowledge of women. There was no relation of VFSS with ages, contraceptive method and hygience habit
Subject(s)
Fluids and Secretions , Syndrome , VaginaABSTRACT
No abstract available.
Subject(s)
Animals , Aquaporins/metabolism , Exocrine Glands/metabolism , Water/metabolismABSTRACT
1. 5-HT inhibits spontaneous fluid secretion as well as stimulated secretion with secretin (cAMP mediated) or ACh (Ca2+ mediated) in the isolated guinea pig pancreatic ducts. 2. The inhibitory effect of 5-HT is reversible and is dependent on the concentration in the range 0.01-0.1 microM, which is much lower than those that affect intestinal motility and secretion. 3. The 5-HT3 receptor in duct cells appears to mediate the inhibitory effect of 5-HT. 4. [Ca2+]i is unlikely to mediate the inhibitory effect of 5-HT.
Subject(s)
5-Methoxytryptamine/pharmacology , Acetylcholine/pharmacology , Animals , Calcium/metabolism , Guinea Pigs , Pancreatic Ducts/metabolism , Pancreatic Ducts/drug effects , Secretin/pharmacology , Serotonin/pharmacology , Serotonin/metabolism , Serotonin/analogs & derivatives , Vasodilator Agents/pharmacologyABSTRACT
Whole gland perfusion technique was applied to rat parotid glands to assess whether amylase affects fluid secretion. Control perfusion without any secretagogue evoked no spontaneous secretion. Carbachol (CCh 1 microM) induced both amylase and fluid secretion with distinctive kinetics. Fluid secretion occurred constantly around 60 microL/g-min, whereas amylase secretion exhibited an initial peak, followed by a rapid decrease to reach a plateau. Isoproterenol (Isop 1 microM) alone did not induce fluid secretion although it evoked amylase secretion as measured in isolated perfused acini. Addition of Isop during CCh stimulation evoked a rapid and large rise in amylase secretion accompanied by small increase in oxygen consumption. Morphological observations carried out by HR SEM and TEM revealed exocytotic profiles following Isop stimulation. CCh stimulation alone seldom showed exocytotic profiles, suggesting a low incidence of amylase secretion during copious fluid secretion. Combined stimulation of CCh and Isop induced both vacuolation and exocytosis along intercellular canaliculi. These findings suggest that control of salivary fluid secretion is independent of the amylase secretion system induced by CCh and/or Isop.
Subject(s)
Male , Rats , Amylases/metabolism , Animals , Carbachol/pharmacology , Cholinergic Agonists/pharmacology , In Vitro Techniques , Isoproterenol/pharmacology , Microscopy, Electron , Microscopy, Electron, Scanning , Oxygen Consumption/physiology , Oxygen Consumption/drug effects , Parotid Gland/ultrastructure , Parotid Gland/metabolism , Parotid Gland/enzymology , Perfusion , Rats, Wistar , Saliva/metabolism , Sympathomimetics/pharmacologyABSTRACT
No abstract available.
Subject(s)
Animals , Isomerism , Saliva/metabolism , Sodium-Hydrogen Exchangers/metabolism , Sodium-Hydrogen Exchangers/physiology , Sodium-Hydrogen Exchangers/chemistryABSTRACT
No abstract available.
Subject(s)
Animals , Isomerism , Saliva/metabolism , Sodium-Hydrogen Exchangers/metabolism , Sodium-Hydrogen Exchangers/physiology , Sodium-Hydrogen Exchangers/chemistryABSTRACT
Autosomal dominant polycystic kidney disease(ADPKD),a common inherited disease,is characterized by massive enlargement of fluid-filled renal cysts.Progressively enlarging cysts compromise normal renal parenchyma,reduce renal function and lead to renal failure.Up to now,the treatment options for ADPKD have been limited to renal replacement therapy by dialysis or by transplantation for patients with end-stage renal failure.Inhibition of cyst fluid secretion,suppression of cyst epithelial cell growth and prevention of renal failure are new approaches to treat PKD.